Leuk Res. 2010 Sep;34(9):1189-94. Epub 2010 Jan 13.

The proliferative response to CpG-ODN stimulation predicts PFS, TTT and OS in patients with chronic lymphocytic leukemia.

Tarnani M, Laurenti L, Longo PG, Piccirillo N, Gobessi S, Mannocci A, Marietti S, Sica S, Leone G, Efremov DG.

Source

Department of Haematology, Catholic University Hospital "A. Gemelli", Largo A. Gemelli, 8, 00168 Rome, Italy.

Abstract

We recently reported that leukemic cells from IgVH-unmutated/progressive CLL more frequently proliferate in response to CpG-ODN stimulation than their corresponding counterparts. Here we evaluated the prognostic impact of this proliferative response in 91 CLL patients. The proliferative response was highly predictive of PFS, TTT and OS in the whole series and refined prognosis in patients with M-CLL. BCR stimulation modulated the response to CpG-ODN, suggesting that the proliferative capacity of the leukemic cells is related to antigen-encounter history. These data support the hypothesis that the capacity of the leukemic cells to respond to external stimuli influences disease progression in CLL.

PMID:: 20074801; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

Oligodeoxyribonucleotides

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

The Akt signaling pathway determines the different proliferative capacity of chronic lymphocytic leukemia B-cells from patients with progressive and stable disease. [Leukemia. 2007]
The Akt signaling pathway determines the different proliferative capacity of chronic lymphocytic leukemia B-cells from patients with progressive and stable disease.
Longo PG, Laurenti L, Gobessi S, Petlickovski A, Pelosi M, Chiusolo P, Sica S, Leone G, Efremov DG. Leukemia. 2007 Jan; 21(1):110-20. Epub 2006 Oct 5.
Immunostimulatory CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lymphocytic leukemia B cells. [Blood. 2000]
Immunostimulatory CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lymphocytic leukemia B cells.
Decker T, Schneller F, Sparwasser T, Tretter T, Lipford GB, Wagner H, Peschel C. Blood. 2000 Feb 1; 95(3):999-1006.
Combined treatment of CpG-oligodeoxynucleotide with Nutlin-3 induces strong immune stimulation coupled to cytotoxicity in B-chronic lymphocytic leukemic (B-CLL) cells. [J Leukoc Biol. 2008]
Combined treatment of CpG-oligodeoxynucleotide with Nutlin-3 induces strong immune stimulation coupled to cytotoxicity in B-chronic lymphocytic leukemic (B-CLL) cells.
Secchiero P, Melloni E, Tiribelli M, Gonelli A, Zauli G. J Leukoc Biol. 2008 Feb; 83(2):434-7. Epub 2007 Nov 12.
Review Prognostic value of biological variables in B-cell chronic lymphocytic leukemia. Can we improve upon clinical parameters? [Haematologica. 1997]
Review Prognostic value of biological variables in B-cell chronic lymphocytic leukemia. Can we improve upon clinical parameters?
Molica S. Haematologica. 1997 Nov-Dec; 82(6):705-9.
Review Evolving view of the in-vivo kinetics of chronic lymphocytic leukemia B cells. [Hematology Am Soc Hematol Educ...]
Review Evolving view of the in-vivo kinetics of chronic lymphocytic leukemia B cells.
Chiorazzi N, Ferrarini M. Hematology Am Soc Hematol Educ Program. 2006; :273-8, 512.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

The proliferative response to CpG-ODN stimulation predicts PFS, TTT and OS in pa...
The proliferative response to CpG-ODN stimulation predicts PFS, TTT and OS in patients with chronic lymphocytic leukemia.
Leuk Res. 2010 Sep ;34(9):1189-94. Epub 2010 Jan 13 .

PubMed
Variables related to materials and preparing for bond strength testing irrespect...
Variables related to materials and preparing for bond strength testing irrespective of the test protocol.
Dent Mater. 2010 Feb ;26(2):e17-23. Epub 2010 Jan 13 .

PubMed
Cognitive-behavioral therapy of insomnia: a clinical case series study of patien...
Cognitive-behavioral therapy of insomnia: a clinical case series study of patients with co-morbid disorders and using hypnotic medications.
Behav Res Ther. 2010 Apr ;48(4):321-7. Epub 2009 Dec 16 .

PubMed
An alternative method for preparation of pandemic influenza strain-specific anti...
An alternative method for preparation of pandemic influenza strain-specific antibody for vaccine potency determination.
Vaccine. 2010 Mar 11 ;28(12):2442-9. Epub 2010 Jan 12 .

PubMed
Identifying pleasant activities for Alzheimer's disease patients: the pleasant e...
Identifying pleasant activities for Alzheimer's disease patients: the pleasant events schedule-AD.
Gerontologist. 1991 Feb ;31(1):124-7.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: