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Biochim Biophys Acta. 2010 May-Jun;1799(5-6):448-53. doi: 10.1016/j.bbagrm.2010.01.003. Epub 2010 Jan 13.

DARPP-32 binds to tra2-beta1 and influences alternative splicing.

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  • 1University of Erlangen-Nuremberg, Institute for Biochemistry, Fahrstrasse 17, 91054 Erlangen, Germany.


The majority of human genes undergo alternative splicing, which is frequently altered in response to physiological stimuli. DARPP-32 (dopamine and cAMP regulated phosphoprotein, 32kDa) is a component of PKA-dependent signaling pathways. Here we show that DARPP-32 binds directly to the splicing factor tra2-beta1 (transformer 2). DARPP-32 changes the usage of tra2-beta1 dependent alternative exons in a concentration-dependent manner, suggesting that the DARPP-32:tra2-beta1 interaction is a molecular link between signaling pathways and pre-mRNA processing.

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