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Phys Med Biol. 2010 Feb 7;55(3):615-22. doi: 10.1088/0031-9155/55/3/004. Epub 2010 Jan 13.

In vivo endoscopic multi-beam optical coherence tomography.

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  • 1Deptartment of Medical Biophysics, University of Toronto, Toronto, Canada.


A multichannel optical coherence tomography (multi-beam OCT) system and an in vivo endoscopic imaging probe were developed using a swept-source OCT system. The distal optics were micro-machined to produce a high numerical aperture, multi-focus fibre optic array. This combination resulted in a transverse design resolution of <10 microm full width half maximum (FWHM) throughout the entire imaging range, while also increasing the signal intensity within the focus of the individual channels. The system was used in a pre-clinical rabbit study to acquire in vivo structural images of the colon and ex vivo images of the oesophagus and trachea. A good correlation between the structural multi-beam OCT images and H&E histology was achieved, demonstrating the feasibility of this high-resolution system and its potential for in vivo human endoscopic imaging.

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