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Am J Clin Nutr. 2010 Mar;91(3):722-8. doi: 10.3945/ajcn.2009.28161. Epub 2010 Jan 13.

Isoflavone intake and risk of lung cancer: a prospective cohort study in Japan.

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  • 1Research Center for Cancer Prevention and Screening, National Cancer Center Tokyo Japan. tshimazu@ncc.go.jp

Abstract

BACKGROUND:

Although case-control studies support the idea that soy foods or isoflavone intake is associated with a decreased risk of lung cancer, little evidence is available from prospective cohort studies. Moreover, no prospective study has addressed this association in men.

OBJECTIVE:

We investigated the association between isoflavone intake and lung cancer incidence.

DESIGN:

We conducted a population-based prospective cohort study in 36,177 men and 40,484 women aged 45-74 y with no history of cancer at baseline in 1995-1999. Participants responded to a validated questionnaire, which included 138 food items. We used Cox proportional hazards regression analysis to estimate the hazard ratios (HRs) and 95% CIs of lung cancer incidence according to isoflavone intake, which was estimated by genistein content from soy foods.

RESULTS:

During 11 y (671,864 person-years) of follow-up, we documented 481 male and 178 female lung cancer cases. In men we found an inverse association between isoflavone intake and risk of lung cancer in never smokers (n = 13,051; multivariate HR in the highest compared with the lowest quartile of isoflavone intake: 0.43; 95% CI: 0.21, 0.90; P for trend = 0.024) but not in current or past smokers. A similar, nonsignificant inverse association was seen in never-smoking women (n = 38,211; HR: 0.67; 95% CI: 0.41, 1.10; P for trend = 0.135). We also tested effect modification by smoking status (P for interaction = 0.085 in men and 0.055 in men and women combined).

CONCLUSION:

In a large-scale, population-based, prospective study in Japan, isoflavone intake was associated with a decreased risk of lung cancer in never smokers.

PMID:
20071645
[PubMed - indexed for MEDLINE]
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