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J Biol. 2009;8(11):101. doi: 10.1186/jbiol205. Epub 2009 Dec 22.

Fishing for the signals that pattern the face.

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  • 1Department of Developmental and Cell Biology, 4462 Natural Sciences II, University of California, Irvine, CA 92697-2300, USA.


Zebrafish are a powerful system for studying the early embryonic events that form the skull and face, as a model for human craniofacial birth defects such as cleft palate. Signaling pathways that pattern the pharyngeal arches (which contain skeletal precursors of the palate, as well as jaws and gills) are discussed in light of a recent paper in BMC Developmental Biology on requirements for Hedgehog signaling in craniofacial development.

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