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Dalton Trans. 2010 Jan 21;39(3):675-96. doi: 10.1039/b912608b. Epub 2009 Nov 23.

Metal chelating systems synthesized using the copper(I) catalyzed azide-alkyne cycloaddition.

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  • 1Institute of Pharmaceutical Science, Department of Chemistry and Applied Bioscience, ETH Zurich, 8093, Zurich, Switzerland.


The copper(I) catalyzed azide-alkyne cycloaddition (CuAAC) is the premier example of a click reaction. The reaction is modular, reliable and easy to perform, providing easy access to molecular diversity. The majority of reported applications of the reaction employ the 1,2,3-triazole as a stable linkage to connect two chemical/biological components, while the potential for metal coordination of the heterocycle itself has received much less attention. In fact, 1,4-functionalized 1,2,3-triazoles are versatile ligands offering several donor sites for metal coordination, including N3, N2 and C5. In this article, we summarize the areas in which the CuAAC has been applied to the synthesis of novel triazole-containing ligands for transition metals.

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