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Cold Spring Harb Perspect Biol. 2009 Jul;1(1):a002873. doi: 10.1101/cshperspect.a002873.

Modular design of immunological synapses and kinapses.

Author information

  • Program in Molecular Pathogenesis, Skirball Institute for Biomolecular Medicine, The Helen L and Martin S Kimmel Center for Biology and Medicine, New York University School of Medicine, New York 10016, USA. michael.dustin@med.nyu.edu

Abstract

The concept of an immunological synapse goes back to the early 1980s with the discovery of the relationship between T-cell antigen receptor mediated Ca(2+) signaling, adhesion, and directed secretion. However, this concept did not gain traction until images were published starting in 1998 that revealed a specific molecular pattern in the interface between T cells and model antigen-presenting cells or supported planar bilayers. The dominant pattern, a ring of adhesion molecules surrounding a central cluster of antigen receptors, was observed in both model systems. Analysis of the origins of this pattern over the past 10 years has presented a solution for a difficult problem in lymphocyte biology--how a highly motile cell can suddenly stop when it encounters a signal delivered by just a few antigenic ligands on the surface of another cell without disabling the sensory machinery of the motile cell. The T lymphocyte actively assembles the immunological synapse pattern following a modular design with roots in actin-myosin-based motility.

PMID:
20066081
[PubMed - indexed for MEDLINE]
PMCID:
PMC2742085
Free PMC Article

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