Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Arch Neurol. 2010 Jan;67(1):80-6. doi: 10.1001/archneurol.2009.297.

Physical exercise, aging, and mild cognitive impairment: a population-based study.

Author information

  • 1Mayo Clinic, 200 First Street SW, Rochester, MN 55905. geda.yonas@mayo.edu.

Abstract

BACKGROUND:

Physical exercise is associated with decreased risk of dementia and Alzheimer disease.

OBJECTIVE:

To investigate whether physical exercise is associated with decreased risk of mild cognitive impairment (MCI).

DESIGN:

Population-based case-control study.

SETTING:

The Mayo Clinic Study of Aging, an ongoing population-based cohort study in Olmsted County, Minnesota.

PARTICIPANTS:

A total of 1324 subjects without dementia who completed a Physical Exercise Questionnaire.

MAIN OUTCOME MEASURES:

An expert consensus panel classified each subject as having normal cognition or MCI based on published criteria.

RESULTS:

We compared the frequency of physical exercise among 198 subjects with MCI with that among 1126 subjects with normal cognition and adjusted the analyses for age, sex, years of education, medical comorbidity, and depression. The odds ratios for any frequency of moderate exercise were 0.61 (95% confidence interval, 0.43-0.88; P = .008) for midlife (age range, 50-65 years) and 0.68 (95% confidence interval, 0.49-0.93; P = .02) for late life. The findings were consistent among men and women. Light exercise and vigorous exercise were not significantly associated with decreased risk of MCI.

CONCLUSION:

In this population-based case-control study, any frequency of moderate exercise performed in midlife or late life was associated with a reduced odds of having MCI.

PMID:
20065133
[PubMed - indexed for MEDLINE]
PMCID:
PMC2919839
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems Icon for PubMed Central
    Loading ...
    Write to the Help Desk