Am J Trop Med Hyg. 2010 Jan;82(1):148-50.

HIV protease inhibitors, indinavir or nelfinavir, augment antimalarial action of artemisinin in vitro.

Mishra LC, Bhattacharya A, Sharma M, Bhasin VK.

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Department of Zoology, University of Delhi, Delhi, India. lokesh20sept@yahoo.co.in

Abstract

Most malaria endemic regions are co-infested with HIV infection. Treatment of one may affect outcome of the other in co-infected individuals. HIV protease inhibitors, indinavir or nelfinavir, are important antiretroviral drugs and artemisinin is central to malaria treatment. We show these protease inhibitors augment the antimalarial activity of artemisinin against P. falciparum in vitro.

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