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Genome Biol. 2010 Jan 8;11(1):R2. doi: 10.1186/gb-2010-11-1-r2.

Integrating phenotype ontologies across multiple species.

Author information

  • 1Genome Dynamics Department, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. cjm@berkeleybop.org

Abstract

Phenotype ontologies are typically constructed to serve the needs of a particular community, such as annotation of genotype-phenotype associations in mouse or human. Here we demonstrate how these ontologies can be improved through assignment of logical definitions using a core ontology of phenotypic qualities and multiple additional ontologies from the Open Biological Ontologies library. We also show how these logical definitions can be used for data integration when combined with a unified multi-species anatomy ontology.

PMID:
20064205
[PubMed - indexed for MEDLINE]
PMCID:
PMC2847714
Free PMC Article

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