Bioorg Med Chem Lett. 2010 Feb 1;20(3):932-4. Epub 2009 Dec 28.

Synthesis, in vitro and in vivo studies of Gd-DTPA-XDA-D1-Glc(OH) complex as a new potential MRI contrast agent.

Ozaki N, Sankar AU, Yamashita M, Aoki T, Tanaka Y, Kimura M, Toda M, Fujie M, Takehara Y, Sakahara H.

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Graduate School of Science and Technology, Shizuoka University, Hamamatsu 432-8561, Japan.

Abstract

A new type of dendritic molecules Gd-DTPA-XDA-D1-Glc(OH), which work as a functionalized ligand coordinating gadolinium(III) ion at the center of their frameworks with two glucose moieties on the molecular surfaces, were readily synthesized with high yield. The structures were established by IR, (1)H, (13)C NMR, and mass spectral studies. Its bio-distribution patterns were evaluated on rats.

PMID:: 20060715; [PubMed - indexed for MEDLINE]

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Synthesis, in vitro and in vivo studies of Gd-DTPA-XDA-D1-Glc(OH) complex as a n...
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