Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cancer Cell. 2010 Jan 19;17(1):13-27. doi: 10.1016/j.ccr.2009.11.020. Epub 2010 Jan 7.

DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia.

Author information

  • 1Department of Medicine, Hematology Oncology Division, Weill Cornell Medical College, New York, NY 10065, USA.

Abstract

We hypothesized that DNA methylation distributes into specific patterns in cancer cells, which reflect critical biological differences. We therefore examined the methylation profiles of 344 patients with acute myeloid leukemia (AML). Clustering of these patients by methylation data segregated patients into 16 groups. Five of these groups defined new AML subtypes that shared no other known feature. In addition, DNA methylation profiles segregated patients with CEBPA aberrations from other subtypes of leukemia, defined four epigenetically distinct forms of AML with NPM1 mutations, and showed that established AML1-ETO, CBFb-MYH11, and PML-RARA leukemia entities are associated with specific methylation profiles. We report a 15 gene methylation classifier predictive of overall survival in an independent patient cohort (p < 0.001, adjusted for known covariates).

Copyright (c) 2010 Elsevier Inc. All rights reserved.

Comment in

PMID:
20060365
[PubMed - indexed for MEDLINE]
PMCID:
PMC3008568
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk