Format

Send to

Choose Destination
See comment in PubMed Commons below
J Biomed Opt. 2009 Nov-Dec;14(6):064026. doi: 10.1117/1.3269677.

Multispecies breath analysis faster than a single respiratory cycle by optical-feedback cavity-enhanced absorption spectroscopy.

Author information

  • 1Universite Joseph Fourier-Grenoble, CNRS UMR5588, Laboratoire de Spectrometrie Physique, 140 Avenue de la Physique, St. Martin d'Heres, F-38042, France. irene.ventrillard@ujf-grenoble.fr

Abstract

We demonstrate a first application, of optical-feedback cavity-enhanced absorption spectroscopy (OF-CEAS) to breath analysis in a medical environment. Noninvasive monitoring of trace species in exhaled air was performed simultaneous to spirometric measurements on patients at Bichat Hospital (Paris). The high selectivity of the OF-CEAS spectrometer and a time response of 0.3 s (limited by sample flow rate) allowed following the evolution of carbon monoxide and methane concentrations during individual respiratory cycles, and resolving variations among different ventilatory patterns. The minimum detectable absorption on this time scale is about 3 x 10(-10) cm(-1). At the working wavelength of the instrument (2.326 microm), this translates to concentration detection limits of approximately 1 ppbv (45 picomolar, or approximately 1.25 microg/m(3)) for CO and 25 ppbv for CH(4), well below concentration values found in exhaled air. This same instrument is also able to provide measurement of NH(3) concentrations with a detection limit of approximately 10 ppbv; however, at present, memory effects do not allow its measurement on fast time scales.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Write to the Help Desk