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Mol Cell Biol. 1991 Apr;11(4):2291-5.

Transcriptional suppression of cellular gene expression by c-Myc.

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  • 1Molecular Biology Research Program, Henry Ford Hospital, Detroit, Michigan 48202.

Abstract

High levels of c-Myc in mouse 3T3-L1 cells specifically suppress the expression of three collagen genes. This effect is exerted through collagen promoter sequences and requires the leucine zipper motif of c-Myc. Our data suggest that an important aspect of c-Myc transforming activity is the ability to suppress specific cellular gene transcription.

PMID:
2005911
[PubMed - indexed for MEDLINE]
PMCID:
PMC359932
Free PMC Article
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