Abstract
An unusual polyprenylated acylphloroglucinol derivative unsubstituted at C-2 and C-6, garcicowin A (1), together with three other new (garcicowins B-D, 2-4) and nine known analogues, was isolated and characterized from the twigs of Garcinia cowa. The structures of 1-4 were elucidated by interpretation of their spectroscopic data. The compounds isolated were evaluated for their cytotoxicity against two cancer cell lines (HT-29 and HCT116) and against normal colon cells (CCD-18Co), and the results demonstrated their selective toxicity toward the cancer cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic* / chemistry
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Antineoplastic Agents, Phytogenic* / pharmacology
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal* / pharmacology
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Garcinia / chemistry
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HCT116 Cells
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HT29 Cells
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Humans
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Phloroglucinol / analogs & derivatives
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Phloroglucinol / chemistry
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Phloroglucinol / isolation & purification
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Phloroglucinol / pharmacology
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Plant Stems / chemistry
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Plants, Medicinal / chemistry*
Substances
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Antineoplastic Agents, Phytogenic
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Drugs, Chinese Herbal
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Phloroglucinol