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Biochem Biophys Res Commun. 2010 Jan 29;392(1):4-8. doi: 10.1016/j.bbrc.2009.12.129. Epub 2010 Jan 7.

Regenerating gene I regulates interleukin-6 production in squamous esophageal cancer cells.

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  • 1Department of Biochemistry, Akita University Graduate School of Medicine, Akita, Japan.


Regenerating gene (REG) I plays important roles in cancer cell biology. The purpose of this study was to determine whether REG I affects cytokine production in cancer cells. We transfected TE-5 and TE-9 squamous esophageal cancer cells with REG Ialpha and Ibeta and examined its effects on cytokine expression. We found that transfecting TE-5 and TE-9 cells with REG I Ialpha and Ibeta led to significantly increased expression of interleukin (IL)-6 mRNA and protein, but it had little or no effect on expression of IL-2, IL-4, IL-5, IL-10, IL-12, IL-13, IL-17A, interferon-gamma, tumor necrosis factor-alpha, granulocyte-colony stimulating factor or transforming growth factor-beta1. The elevated IL-6 expression seen in REG Ialpha transfectants was silenced by small interfering RNA-mediated knockdown. These finding suggest that REG I may act through IL-6 to exert effects on squamous esophageal cancer cell biology.

Copyright (c) 2009 Elsevier Inc. All rights reserved.

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