Format

Send to:

Choose Destination
See comment in PubMed Commons below
Am J Reprod Immunol. 2010 Jun;63(6):434-44. doi: 10.1111/j.1600-0897.2009.00794.x. Epub 2010 Jan 4.

The unique properties of uterine NK cells.

Author information

  • 1The Lautenberg Center for General and Tumor Immunology, The Hebrew University, Hadassah Medical School, IMRIC, Jerusalem, Israel.

Abstract

Natural killer (NK) cells are lymphocytes of the innate immunity system that are able to kill various hazardous pathogens and tumors. However, it is now widely accepted that NK cells also possess non-destructive functions, as has been demonstrated for uterine NK cells. Here, we review the unique properties of the NK cells in the uterine mucosa, prior to and during pregnancy. We discuss the phenotype and function of mouse and human endometrial and decidual NK cells and suggest that the major function of decidual NK cells is to assist in fetal development. We further discuss the origin of decidual NK cells and suggest several possibilities that might explain their accumulation in the decidua during pregnancy.

PMID:
20055791
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Blackwell Publishing
    Loading ...
    Write to the Help Desk