The Churg-Strauss syndrome (CSS) is a systemic vasculitis. The symptoms of CSS normally occur between the ages of 20 and 40. We present a case of a 60-year-old man with the CSS evolving in three phases. The initial symptoms included bronchial asthma and inflammation of the ethmoid sinuses. Later, the patient was diagnosed with peripheral blood eosinophilia, pulmonary changes, skin changes and neurological symptoms that progressed to multiple mononeuropathy. Electrophysiological tests confirmed progressive damage of the peripheral nervous system. An improvement of the patient's neurological state was observed after application of corticosteroids and rehabilitation. CSS is one of the causes of multiple mononeuropathy and should be taken into account in differential diagnosis. In patients with bronchial asthma, hypereosinophilia and progressive damage of many nerves, the syndrome is diagnosed in accordance with the criteria defined by the American College of Rheumatology.