Nat Rev Genet. 2010 Feb;11(2):97-108. Epub 2010 Jan 6.

The evolution of gene duplications: classifying and distinguishing between models.

Source

Graduate University for Advanced Studies, Hayama, Kanagawa 240-0193, Japan. innan_hideki@soken.ac.jp

Abstract

Gene duplications and their subsequent divergence play an important part in the evolution of novel gene functions. Several models for the emergence, maintenance and evolution of gene copies have been proposed. However, a clear consensus on how gene duplications are fixed and maintained in genomes is lacking. Here, we present a comprehensive classification of the models that are relevant to all stages of the evolution of gene duplications. Each model predicts a unique combination of evolutionary dynamics and functional properties. Setting out these predictions is an important step towards identifying the main mechanisms that are involved in the evolution of gene duplications.

PMID:: 20051986; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

Review

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Gene conversion and functional divergence in the beta-globin gene family. [J Mol Evol. 2004]
Gene conversion and functional divergence in the beta-globin gene family.
Aguileta G, Bielawski JP, Yang Z. J Mol Evol. 2004 Aug; 59(2):177-89.
Review Gene duplication: past, present and future. [Semin Cell Dev Biol. 1999]
Review Gene duplication: past, present and future.
Holland PW. Semin Cell Dev Biol. 1999 Oct; 10(5):541-7.
The evolution of the calpain family as reflected in paralogous chromosome regions. [J Mol Evol. 1999]
The evolution of the calpain family as reflected in paralogous chromosome regions.
Jékely G, Friedrich P. J Mol Evol. 1999 Aug; 49(2):272-81.
Evolutionary history of the UCP gene family: gene duplication and selection. [BMC Evol Biol. 2008]
Evolutionary history of the UCP gene family: gene duplication and selection.
Hughes J, Criscuolo F. BMC Evol Biol. 2008 Nov 3; 8:306. Epub 2008 Nov 3.
Review The evolution of gene duplicates. [Adv Genet. 2002]
Review The evolution of gene duplicates.
Otto SP, Yong P. Adv Genet. 2002; 46:451-83.

See reviews... See all...

Cited by 54 PubMed Central articles

Proteome-wide analysis of functional divergence in bacteria: exploring a host of ecological adaptations. [PLoS One. 2012]
Proteome-wide analysis of functional divergence in bacteria: exploring a host of ecological adaptations.
Caffrey BE, Williams TA, Jiang X, Toft C, Hokamp K, Fares MA. PLoS One. 2012; 7(4):e35659. Epub 2012 Apr 26.
Family size and turnover rates among several classes of small non-protein-coding RNA genes in Caenorhabditis nematodes. [Genome Biol Evol. 2012]
Family size and turnover rates among several classes of small non-protein-coding RNA genes in Caenorhabditis nematodes.
Wang PP, Ruvinsky I. Genome Biol Evol. 2012 Jan; 4(4):565-74. Epub 2012 Mar 30.
Evolution of functional specialization and division of labor. [Proc Natl Acad Sci U S A. 2012]
Evolution of functional specialization and division of labor.
Rueffler C, Hermisson J, Wagner GP. Proc Natl Acad Sci U S A. 2012 Feb 7; 109(6):E326-35. Epub 2012 Jan 24.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The evolution of gene duplications: classifying and distinguishing between model...
The evolution of gene duplications: classifying and distinguishing between models.
Nat Rev Genet. 2010 Feb ;11(2):97-108. Epub 2010 Jan 6 .

PubMed
Two novel human anti-ErbB2 immunoagents are active on trastuzumab-resistant tumo...
Two novel human anti-ErbB2 immunoagents are active on trastuzumab-resistant tumours.
Br J Cancer. 2010 Feb 2 ;102(3):513-9. Epub 2010 Jan 5 .

PubMed
Combination therapy: intermittent sorafenib with bevacizumab yields activity and...
Combination therapy: intermittent sorafenib with bevacizumab yields activity and decreased toxicity.
Br J Cancer. 2010 Feb 2 ;102(3):495-9. Epub 2010 Jan 5 .

PubMed
Enhanced antitumor effects of an engineered measles virus Edmonston strain expre...
Enhanced antitumor effects of an engineered measles virus Edmonston strain expressing the wild-type N, P, L genes on human renal cell carcinoma.
Mol Ther. 2010 Mar ;18(3):544-51. Epub 2010 Jan 5 .

PubMed
Normal functional range of motion of the cervical spine during 15 activities of ...
Normal functional range of motion of the cervical spine during 15 activities of daily living.
J Spinal Disord Tech. 2010 Feb ;23(1):15-21.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: