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Am J Clin Oncol. 2010 Dec;33(6):619-23. doi: 10.1097/COC.0b013e3181c4c6e1.

A surveillance, epidemiology, and end results registry analysis of prostate cancer modality time trends by age.

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  • 1Department of Radiation Oncology, Emory University, Atlanta, GA, USA.

Abstract

OBJECTIVE:

To use the Surveillance, Epidemiology, and End Results (SEER) registry to analyze age-specific time trends in the use of radiotherapy (RT) (external beam radiotherapy [EBRT], brachytherapy [brachy], and combination therapy [combo]) as first-line treatment for prostate cancer.

METHODS:

A total of 820,649 prostate cancer patients in the SEER public-use registry (1973-2004) with diagnosis year, treatment, and age information available were identified. Modality use time-trend curves were plotted for patients 45 to 85+ years of age, grouped in 5-year intervals. A nonparametric (Spearman) test was used to assess the correlation between diagnosis year and (a) percentage use of RT and (b) relative percentage use of EBRT, brachy, and combo therapy.

RESULTS:

Over the study period from 1973 to 2004, RT use increased in patients ≥65 years of age, but has remained stable in patients <65 years of age. All age groups experienced a similar relative rise in the use of brachy and combo therapy, with brachy use surpassing combo use in approximately year 2000.

CONCLUSIONS:

Trends in treatment choice for early prostate cancer generally reflect treatment advances, but do not appear to be uniform among all age groups. The SEER database is a valuable asset for analyzing these trends and can be used to investigate age-specific treatment patterns.

PMID:
20051808
[PubMed - indexed for MEDLINE]
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