My NCBISign In

Display Settings:

Format

Send to:

Choose Destination
    J Clin Invest. 2010 Jan;120(1):60-70. doi: 10.1172/JCI41158.

    Enabling stem cell therapies through synthetic stem cell-niche engineering.

    Peerani R, Zandstra PW.

    Source

    Institute of Biomaterials and Biomedical Engineering, and Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.

    Abstract

    Enabling stem cell-targeted therapies requires an understanding of how to create local microenvironments (niches) that stimulate endogenous stem cells or serve as a platform to receive and guide the integration of transplanted stem cells and their derivatives. In vivo, the stem cell niche is a complex and dynamic unit. Although components of the in vivo niche continue to be described for many stem cell systems, how these components interact to modulate stem cell fate is only beginning to be understood. Using the HSC niche as a model, we discuss here microscale engineering strategies capable of systematically examining and reconstructing individual niche components. Synthetic stem cell-niche engineering may form a new foundation for regenerative therapies.

    PMID:
    20051637
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2798701
    Free PMC Article

    Images from this publication.See all images (4) Free text

    Figure 2
    Figure 4
    Figure 1
    Figure 3

    Publication Types, MeSH Terms, Substances, Grant Support

    Publication Types

    MeSH Terms

    Substances

    Grant Support

    LinkOut - more resources

    Full Text Sources

    Other Literature Sources

    Medical

    Molecular Biology Databases

      Supplemental Content

      Icon for Journal of Clinical Investigation Icon for PubMed Central

      Save items

      loading

      Related citations in PubMed

      See reviews... See all...

      Cited by 1 PubMed Central article

      • Optimizing stem cell culture. [J Cell Biochem. 2010]
        Optimizing stem cell culture.
        van der Sanden B, Dhobb M, Berger F, Wion D. J Cell Biochem. 2010 Nov 1; 111(4):801-7.

      Related information

      • Related Citations
        Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
      • Compound (MeSH Keyword)
        PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
      • References for this PMC Article
        Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
      • Substance (MeSH Keyword)
        PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
      • Free in PMC
        Free full text articles in PMC
      • Cited in PMC
        Full-text articles in the PubMed Central Database that cite the current articles.

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...
      You are here: NCBI > Literature > PubMed
      Write to the Help Desk