Cancer Prev Res (Phila). 2010 Jan;3(1):8-11.

Targeting ornithine decarboxylase for the prevention of nonmelanoma skin cancer in humans.

Source

Department of Dermatology, UAB Skin Diseases Research Center and UAB Comprehensive Cancer Center, The University of Alabama at Birmingham, 35294-0019, USA. celmets@uab.edu

Abstract

Bailey et al. report in this issue of the journal (beginning on page 35) one of the first successful trials of basal cell carcinoma (BCC) prevention. Oral alpha-difluoromethyl-dl-ornithine (DFMO) reduced new BCCs in patients with a prior history of nonmelanoma skin cancer. DFMO is an inhibitor of ornithine decarboxylase, a key enzyme in the polyamine biosynthetic pathway. This perspective on Bailey et al. discusses our knowledge of the contribution of polyamines to BCC pathogenesis, how this knowledge advanced the development of a new method to prevent BCCs, and prospects for future studies of DFMO in BCC prevention.

Comment on

Cancer Prev Res (Phila). 2010 Jan;3(1):35-47.

PMID:: 20051367; [PubMed - indexed for MEDLINE]
PMCID:: PMC2926793

Free PMC Article

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Skin Cancer - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

A randomized, double-blind, placebo-controlled phase 3 skin cancer prevention study of {alpha}-difluoromethylornithine in subjects with previous history of skin cancer. [Cancer Prev Res (Phila). 2010]
A randomized, double-blind, placebo-controlled phase 3 skin cancer prevention study of {alpha}-difluoromethylornithine in subjects with previous history of skin cancer.
Bailey HH, Kim K, Verma AK, Sielaff K, Larson PO, Snow S, Lenaghan T, Viner JL, Douglas J, Dreckschmidt NE, et al. Cancer Prev Res (Phila). 2010 Jan; 3(1):35-47.
Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- mice. [J Clin Invest. 2004]
Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- mice.
Tang X, Kim AL, Feith DJ, Pegg AE, Russo J, Zhang H, Aszterbaum M, Kopelovich L, Epstein EH Jr, Bickers DR, et al. J Clin Invest. 2004 Mar; 113(6):867-75.
Review Skin cancer chemoprevention: strategies to save our skin. [Recent Results Cancer Res. 2003]
Review Skin cancer chemoprevention: strategies to save our skin.
Einspahr JG, Bowden GT, Alberts DS. Recent Results Cancer Res. 2003; 163:151-64; discussion 264-6.
Occurrence of other cancers among patients with prior basal cell and squamous cell skin cancer. [Cancer Epidemiol Biomarkers Pr...]
Occurrence of other cancers among patients with prior basal cell and squamous cell skin cancer.
Karagas MR, Greenberg ER, Mott LA, Baron JA, Ernster VL. Cancer Epidemiol Biomarkers Prev. 1998 Feb; 7(2):157-61.
Review Polyamines and nonmelanoma skin cancer. [Toxicol Appl Pharmacol. 2007]
Review Polyamines and nonmelanoma skin cancer.
Gilmour SK. Toxicol Appl Pharmacol. 2007 Nov 1; 224(3):249-56. Epub 2006 Nov 29.

See reviews... See all...

Cited by 2 PubMed Central articles

Deciphering squamous cell carcinoma using multidimensional genomic approaches. [J Skin Cancer. 2011]
Deciphering squamous cell carcinoma using multidimensional genomic approaches.
Gibb EA, Enfield KS, Tsui IF, Chari R, Lam S, Alvarez CE, Lam WL. J Skin Cancer. 2011; 2011:541405. Epub 2010 Dec 27.
Review Pathogenesis of nonmelanoma skin cancers in organ transplant recipients. [Arch Biochem Biophys. 2011]
Review Pathogenesis of nonmelanoma skin cancers in organ transplant recipients.
Athar M, Walsh SB, Kopelovich L, Elmets CA. Arch Biochem Biophys. 2011 Apr 15; 508(2):159-63. Epub 2011 Jan 11.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Targeting ornithine decarboxylase for the prevention of nonmelanoma skin cancer ...
Targeting ornithine decarboxylase for the prevention of nonmelanoma skin cancer in humans.
Cancer Prev Res (Phila). 2010 Jan ;3(1):8-11.

PubMed
Differential processing of metacognitive evaluation and the neural circuitry of ...
Differential processing of metacognitive evaluation and the neural circuitry of the self and others in schizophrenia: a pilot study.
Schizophr Res. 2010 Feb ;116(2-3):252-8. Epub 2010 Jan 3 .

PubMed
Heterologous HIV-based lentiviral/adenoviral vectors immunizations result in enh...
Heterologous HIV-based lentiviral/adenoviral vectors immunizations result in enhanced HIV-specific immunity.
Vaccine. 2010 Apr 30 ;28(20):3617-24. Epub 2010 Jan 4 .

PubMed
The REFLECT statement: methods and processes of creating reporting guidelines fo...
The REFLECT statement: methods and processes of creating reporting guidelines for randomized controlled trials for livestock and food safety.
J Food Prot. 2010 Jan ;73(1):132-9.

PubMed
Hemoglobin Terre Haute arginine beta 106. A posthumous correction to the origina...
Hemoglobin Terre Haute arginine beta 106. A posthumous correction to the original structure of hemoglobin Indianapolis.
J Biol Chem. 1991 Mar 25 ;266(9):5798-800.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Targeting ornithine decarboxylase for the prevention of nonmelanoma skin cancer in humans.

Source

Abstract

Comment on

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 2 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information