Clin Endocrinol (Oxf). 2010 Jun;72(6):721-8. Epub 2009 Dec 29.

The continuum of growth hormone-IGF-I axis defects causing short stature: diagnostic and therapeutic challenges.

Source

Department of Endocrinology, William Harvey Research Institute, Barts and the Royal London School of Medicine & Dentistry, London, UK. m.o.savage@qmul.ac.uk

Abstract

The growth hormone (GH)-IGF-I axis is essential for normal foetal and childhood growth. Defects at different sites in the axis frequently result in short stature which may compromise adult height. We describe a continuum of clinically relevant abnormalities from GH deficiency through to GH resistance and discuss the implementation and interpretation of investigations. We consider appropriate therapy for patients with abnormal auxology and subnormal adult height prognosis, highlighting new data to clarify therapeutic choices leading to optimal clinical outcome.

PMID:: 20050859; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Supplemental Content

Save items

Related citations in PubMed

Review Pathophysiology, assessment and management of the child with growth hormone resistance. [Pediatr Endocrinol Rev. 2010]
Review Pathophysiology, assessment and management of the child with growth hormone resistance.
Savage MO, Cohen L, Cohen AJ, Cohen P, Saenger PH. Pediatr Endocrinol Rev. 2010 Jun; 7(4):347-56.
Review The GH-IGF-I axis in children with idiopathic short stature. [Trends Endocrinol Metab. 2002]
Review The GH-IGF-I axis in children with idiopathic short stature.
Blair JC, Savage MO. Trends Endocrinol Metab. 2002 Oct; 13(8):325-30.
Short stature and decreased insulin-like growth factor I (IGF-I)/growth hormone (GH)-ratio in an adult GH-deficient patient pointing to additional partial GH insensitivity due to a R179C mutation of the growth hormone receptor. [Growth Horm IGF Res. 2007]
Short stature and decreased insulin-like growth factor I (IGF-I)/growth hormone (GH)-ratio in an adult GH-deficient patient pointing to additional partial GH insensitivity due to a R179C mutation of the growth hormone receptor.
Meyer S, Ipek M, Keth A, Minnemann T, von Mach MA, Weise A, Ittner JR, Nawroth PP, Plöckinger U, Stalla GK, et al. Growth Horm IGF Res. 2007 Aug; 17(4):307-14. Epub 2007 Apr 25.
Review Molecular defects in the growth hormone-IGF axis. [Indian J Pediatr. 2005]
Review Molecular defects in the growth hormone-IGF axis.
Lee J, Menon RK. Indian J Pediatr. 2005 Feb; 72(2):145-8.
Review New molecular mechanisms of GH resistance. [Eur J Endocrinol. 2004]
Review New molecular mechanisms of GH resistance.
Rosenfeld RG, Hwa V. Eur J Endocrinol. 2004 Aug; 151 Suppl 1:S11-5.

See reviews... See all...

Cited by 1 PubMed Central article

Review Mechanisms and pathways of growth failure in primordial dwarfism. [Genes Dev. 2011]
Review Mechanisms and pathways of growth failure in primordial dwarfism.
Klingseisen A, Jackson AP. Genes Dev. 2011 Oct 1; 25(19):2011-24.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The continuum of growth hormone-IGF-I axis defects causing short stature: diagno...
The continuum of growth hormone-IGF-I axis defects causing short stature: diagnostic and therapeutic challenges.
Clin Endocrinol (Oxf). 2010 Jun ;72(6):721-8. Epub 2009 Dec 29 .

PubMed
Quercetin and its major metabolites selectively modulate cyclic GMP-dependent re...
Quercetin and its major metabolites selectively modulate cyclic GMP-dependent relaxations and associated tolerance in pig isolated coronary artery.
Br J Pharmacol. 2010 Feb 1 ;159(3):566-75. Epub 2009 Dec 24 .

PubMed
Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory...
Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis.
Br J Pharmacol. 2010 Feb ;159(4):842-55. Epub 2009 Dec 24 .

PubMed
Sex differences in animal models of depression and antidepressant response.
Sex differences in animal models of depression and antidepressant response.
Basic Clin Pharmacol Toxicol. 2010 Mar ;106(3):226-33. Epub 2009 Dec 30 .

PubMed
Physical activity and lung cancer among non-smokers: a pilot molecular epidemiol...
Physical activity and lung cancer among non-smokers: a pilot molecular epidemiological study within EPIC.
Biomarkers. 2010 Feb ;15(1):20-30.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: