J Clin Psychiatry. 1991 Mar;52(3):105-7.

Clozapine-induced neuroleptic malignant syndrome.

Source

Department of Psychiatry, University of Wisconsin, Madison.

Abstract

Neuroleptic malignant syndrome (NMS), a rare but serious side effect of psychotropic drugs, is usually attributed to blockade of striatal and hypothalamic dopaminergic tracts. Clozapine is an atypical antipsychotic that has minimal extrapyramidal effects and might not be expected to cause NMS. The authors report the development of NMS in a 30-year-old white man after three 25-mg clozapine doses. To their knowledge, this is the first case of NMS linked with clozapine in which concurrent psychotropic medications cannot be implicated.

Comment in

J Clin Psychiatry. 1992 Aug;53(8):294-5.

PMID:: 2005072; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

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Case Reports

MeSH Terms

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Clozapine

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CLOZAPINE - HSDB

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Related citations in PubMed

Catatonia as a risk factor for the development of neuroleptic malignant syndrome: report of a case following treatment with clozapine. [World J Biol Psychiatry. 2009]
Catatonia as a risk factor for the development of neuroleptic malignant syndrome: report of a case following treatment with clozapine.
Paparrigopoulos T, Tzavellas E, Ferentinos P, Mourikis I, Liappas J. World J Biol Psychiatry. 2009; 10(1):70-3.
Review [Neuroleptic malignant syndrome and atypical antipsychotics: a brief review]. [Encephale. 2008]
Review [Neuroleptic malignant syndrome and atypical antipsychotics: a brief review].
Khaldi S, Kornreich C, Choubani Z, Gourevitch R. Encephale. 2008 Dec; 34(6):618-24. Epub 2008 Apr 2.
Review [Clozapine: a neuroleptic at risk of provoking neuroleptic malignant syndrome (NMS) or an alternative neuroleptic with positive NMS case histories?]. [Fortschr Neurol Psychiatr. 1993]
Review [Clozapine: a neuroleptic at risk of provoking neuroleptic malignant syndrome (NMS) or an alternative neuroleptic with positive NMS case histories?].
Weller M, Kornhuber J. Fortschr Neurol Psychiatr. 1993 Jun; 61(6):217-22.
Neuroleptic malignant syndrome associated with clozapine treatment. [Ann Clin Psychiatry. 1995]
Neuroleptic malignant syndrome associated with clozapine treatment.
Tsai G, Crisostomo G, Rosenblatt ML, Stern TA. Ann Clin Psychiatry. 1995 Jun; 7(2):91-5.
Neuroleptic malignant syndrome associated with clozapine use. [J Clin Psychiatry. 1991]
Neuroleptic malignant syndrome associated with clozapine use.
Anderson ES, Powers PS. J Clin Psychiatry. 1991 Mar; 52(3):102-4.

See reviews... See all...

Cited by 1 PubMed Central article

When can patients with potentially life-threatening adverse effects be rechallenged with clozapine? A systematic review of the published literature. [Schizophr Res. 2012]
When can patients with potentially life-threatening adverse effects be rechallenged with clozapine? A systematic review of the published literature.
Manu P, Sarpal D, Muir O, Kane JM, Correll CU. Schizophr Res. 2012 Feb; 134(2-3):180-6. Epub 2011 Nov 22.

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