Genes Dev. 2010 Jan 1;24(1):1-4.

Tumorigenicity of the miR-17-92 cluster distilled.

Source

Division of Gene Regulation, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

Abstract

The miR-17-92 gene cluster, with its six different mature microRNAs (miRNAs), has an established oncogenic function. However, the oncogenic contribution of each individual miRNA in the cluster has not been assigned. Two studies published in the December 15, 2009, issue of Genes & Development by Mu and colleagues (pp. 2806-2811) and Olive and colleagues (pp. 2839-2849) dissected the miR-17-92 cluster to its individual miRNA components and identified their relative contributions to oncogenic transformation in mouse model systems.

Comment on

PMID:: 20047995; [PubMed - indexed for MEDLINE]
PMCID:: PMC2802185

Free PMC Article

Images from this publication.See all images (1) Free text

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

MicroRNAs

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

Functional links between clustered microRNAs: suppression of cell-cycle inhibitors by microRNA clusters in gastric cancer. [Nucleic Acids Res. 2009]
Functional links between clustered microRNAs: suppression of cell-cycle inhibitors by microRNA clusters in gastric cancer.
Kim YK, Yu J, Han TS, Park SY, Namkoong B, Kim DH, Hur K, Yoo MW, Lee HJ, Yang HK, et al. Nucleic Acids Res. 2009 Apr; 37(5):1672-81. Epub 2009 Jan 19.
MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis. [Proc Natl Acad Sci U S A. 2008]
MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis.
Pichiorri F, Suh SS, Ladetto M, Kuehl M, Palumbo T, Drandi D, Taccioli C, Zanesi N, Alder H, Hagan JP, et al. Proc Natl Acad Sci U S A. 2008 Sep 2; 105(35):12885-90. Epub 2008 Aug 26.
Review Embryonic stem cell microRNAs: defining factors in induced pluripotent (iPS) and cancer (CSC) stem cells? [Curr Stem Cell Res Ther. 2009]
Review Embryonic stem cell microRNAs: defining factors in induced pluripotent (iPS) and cancer (CSC) stem cells?
Gunaratne PH. Curr Stem Cell Res Ther. 2009 Sep; 4(3):168-77.
Oncogenic potential of the miR-106-363 cluster and its implication in human T-cell leukemia. [Cancer Res. 2007]
Oncogenic potential of the miR-106-363 cluster and its implication in human T-cell leukemia.
Landais S, Landry S, Legault P, Rassart E. Cancer Res. 2007 Jun 15; 67(12):5699-707.
Review MicroRNAs: small but potent oncogenes or tumor suppressors. [Curr Opin Investig Drugs. 2006]
Review MicroRNAs: small but potent oncogenes or tumor suppressors.
Lee YS, Dutta A. Curr Opin Investig Drugs. 2006 Jun; 7(6):560-4.

See reviews... See all...

Cited by 3 PubMed Central articles

MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure. [Aging Cell. 2011]
MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure.
van Almen GC, Verhesen W, van Leeuwen RE, van de Vrie M, Eurlings C, Schellings MW, Swinnen M, Cleutjens JP, van Zandvoort MA, Heymans S, et al. Aging Cell. 2011 Oct; 10(5):769-79. Epub 2011 May 25.
Review Cancer epigenetics: above and beyond. [Toxicol Mech Methods. 2011]
Review Cancer epigenetics: above and beyond.
Brait M, Sidransky D. Toxicol Mech Methods. 2011 May; 21(4):275-88.
Review Apoptotic cell signaling in cancer progression and therapy. [Integr Biol (Camb). 2011]
Review Apoptotic cell signaling in cancer progression and therapy.
Plati J, Bucur O, Khosravi-Far R. Integr Biol (Camb). 2011 Apr; 3(4):279-96. Epub 2011 Feb 22.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Tumorigenicity of the miR-17-92 cluster distilled.
Tumorigenicity of the miR-17-92 cluster distilled.
Genes Dev. 2010 Jan 1 ;24(1):1-4.

PubMed
Adult children's problems and successes: implications for intergenerational ambi...
Adult children's problems and successes: implications for intergenerational ambivalence.
J Gerontol B Psychol Sci Soc Sci. 2010 Mar ;65B(2):145-53. Epub 2010 Jan 4 .

PubMed
Lung cancer and occupation in a population-based case-control study.
Lung cancer and occupation in a population-based case-control study.
Am J Epidemiol. 2010 Feb 1 ;171(3):323-33. Epub 2010 Jan 4 .

PubMed
Site-specific chromosomal integration of large synthetic constructs.
Site-specific chromosomal integration of large synthetic constructs.
Nucleic Acids Res. 2010 Apr ;38(6):e92. Epub 2010 Jan 4 .

PubMed
Location analysis for the estrogen receptor-alpha reveals binding to diverse ERE...
Location analysis for the estrogen receptor-alpha reveals binding to diverse ERE sequences and widespread binding within repetitive DNA elements.
Nucleic Acids Res. 2010 Apr ;38(7):2355-68. Epub 2010 Jan 4 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: