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    Genomics. 1991 Jan;9(1):90-5.

    Identification of CpG islands in a physical map encompassing the Friedreich's ataxia locus.

    Wilkes D, Shaw J, Anand R, Riley J, Winter P, Wallis J, Driesel AG, Williamson R, Chamberlain S.

    Source

    Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, London, England.

    Abstract

    The Friedreich's ataxia locus has been previously assigned to chromosome 9q 13-21.1 by the demonstration of tight linkage to two anonymous DNA markers. MCT112 (Z greater than 80, theta = 0) and DR47 (Z greater than 50, theta = 0). The absence of recombination between these three loci has prevented the resolution of gene/probe order in this region, impeding strategies for gene isolation. We report physical mapping over a 4-Mb genomic interval, linking the markers MCT112 and DR47 on a common 460-kb NotI fragment and identifying 11 CpG islands in the 1.7-Mb interval most likely to contain the Friedreich's ataxia locus. Four of these islands were detected only by analysis of three YAC clones spanning a 700-kb interval including the MCT112/DR47 cluster. Without clear evidence of the precise location of the disease locus from recombination events, each of these regions must be considered as specifying a potential "candidate" sequence for the mutated gene.

    PMID:
    2004770
    [PubMed - indexed for MEDLINE]

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