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Appl Radiat Isot. 2010 Jul-Aug;68(7-8):1349-53. doi: 10.1016/j.apradiso.2009.12.023. Epub 2009 Dec 21.

Standardization and measurement of gamma-ray probability per decay of 177Lu.

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  • 1Instituto de Pesquisas Energ√©ticas e Nucleares, IPEN-CNEN/SP, Centro do Reator de Pesquisas-CRPq, S√£o Paulo, SP, Brazil.


The procedure followed by the Nuclear Metrology Laboratory (LMN), at the Nuclear and Energy Research Institute (IPEN), for the primary standardization of (177)Lu is described. This radionuclide is widely used in radiopharmacy due to its convenient half-life and emitted beta ray energies. The (177)Lu solution was supplied during an international comparison sponsored by BIPM in 2009 and the primary standardization has been accomplished by the 4pibeta-gamma coincidence method using a proportional counter in 4pi geometry coupled with two NaI(Tl) scintillation counters. The beta efficiency was varied by placing Collodion and aluminum absorbers over and under the radioactive source. The (177)Lu calibrated sources were also measured in a previously calibrated HPGe spectrometer, in order to obtain the emission probability per decay for the selected gamma-ray transitions. The experimental extrapolation curves were also compared with Monte Carlo simulations by means of code ESQUEMA developed at the LMN.

Copyright 2009 Elsevier Ltd. All rights reserved.

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