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Bioorg Med Chem. 2010 Feb;18(3):1252-8. Epub 2009 Dec 16.

Proteasome inhibition in human breast cancer cells with high catechol-O-methyltransferase activity by green tea polyphenol EGCG analogs.

Huo C, Yang H, Cui QC, Dou QP, Chan TH.

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Department of Chemistry, McGill University, Montreal, Quebec, Canada.

Abstract

A pro-drug 8 of a synthetic analog 7 is more active in its antiproliferative activity against human breast cancer MDA-MB-231 cells possessing high catechol-O-methyltransferase (COMT) activity than the pro-drugs of EGCG and the analog 5. The higher activity of 8 is attributed to it not being a substrate of COMT.

Copyright (c) 2009 Elsevier Ltd. All rights reserved.

PMID:: 20045338; [PubMed - indexed for MEDLINE]
PMCID:: PMC2819655

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