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    Bioorg Med Chem Lett. 2010 Feb 1;20(3):997-9. Epub 2009 Dec 21.

    Bicyclic peptides as potent inhibitors of histone deacetylases: optimization of alkyl loop length.

    Islam NM, Kato T, Nishino N, Kim HJ, Ito A, Yoshida M.

    Source

    Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Kitakyushu 808-0196, Japan.

    Abstract

    Bicyclic tetrapeptide hydroxamic acids were prepared as histone deacetylase (HDAC) inhibitors, and the evaluated inhibitory activity shows that they are potent against HDAC1 and HDAC4. The in vivo activity depends on alkyl loop length.

    Copyright (c) 2009 Elsevier Ltd. All rights reserved.

    PMID:
    20045316
    [PubMed - indexed for MEDLINE]

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