(a) In the amygdala, BOLD response increases parametrically to familiar, novel common and novel uncommon images. Response is greater for novel common relative to familiar images for both the left amygdala, t(28) = 4.49, p = .0001, and right amygdala, t(28) = 4.04, p = .0004. Amygdala response is also increased for novel uncommon images compared to novel common for both left, t(28) = 2.14, p = .04, and right, t(28) = 2.49, p = .02, hemispheres. (b) Left and right hippocampi show increased responses to novel common relative to familiar pictures (t(28) = 6.21, p = .0004 and t(28) = 6.66, p = .0001,respectively), but do not respond differentially to the two types of novel pictures (both ps > .59; novel uncommon = novel common). Error bars indicate SEM.