Biochem Biophys Res Commun. 2010 Jan 22;391(4):1762-8. doi: 10.1016/j.bbrc.2009.12.150. Epub 2009 Dec 31.

Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis.

Kaur J, Adya R, Tan BK, Chen J, Randeva HS.

Source

Endocrinology and Metabolism Research Group, University of Warwick Medical School, Gibbet Hill Road, Coventry CV4 7AL, UK.

Abstract

Chemerin acting via its distinct G protein-coupled receptor CMKLR1 (ChemR23), is a novel adipokine, circulating levels of which are raised in inflammatory states. Chemerin shows strong correlation with various facets of the metabolic syndrome; these states are associated with an increased incidence of cardiovascular disease (CVD) and dysregulated angiogenesis. We therefore, investigated the regulation of ChemR23 by pro-inflammatory cytokines and assessed the angiogenic potential of chemerin in human endothelial cells (EC). We have demonstrated the novel presence of ChemR23 in human ECs and its significant up-regulation (P<0.001) by pro-inflammatory cytokines, TNF-alpha, IL-1beta and IL-6. More importantly, chemerin was potently angiogenic, as assessed by conducting functional in-vitro angiogenic assays; chemerin also dose-dependently induced gelatinolytic (MMP-2 & MMP-9) activity of ECs (P<0.001). Furthermore, chemerin dose-dependently activated PI3K/Akt and MAPKs pathways (P<0.01), key angiogenic and cell survival cascades. Our data provide the first evidence of chemerin-induced endothelial angiogenesis and MMP production and activity.

PMID:: 20044979; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Miscellaneous

NCI CPTC Antibody Characterization Program

Supplemental Content

Save items

Related citations in PubMed

Human articular chondrocytes express ChemR23 and chemerin; ChemR23 promotes inflammatory signalling upon binding the ligand chemerin(21-157). [Arthritis Res Ther. 2010]
Human articular chondrocytes express ChemR23 and chemerin; ChemR23 promotes inflammatory signalling upon binding the ligand chemerin(21-157).
Berg V, Sveinbjörnsson B, Bendiksen S, Brox J, Meknas K, Figenschau Y. Arthritis Res Ther. 2010; 12(6):R228. Epub 2010 Dec 30.
Adipokine resistin promotes in vitro angiogenesis of human endothelial cells. [Cardiovasc Res. 2006]
Adipokine resistin promotes in vitro angiogenesis of human endothelial cells.
Mu H, Ohashi R, Yan S, Chai H, Yang H, Lin P, Yao Q, Chen C. Cardiovasc Res. 2006 Apr 1; 70(1):146-57. Epub 2006 Mar 3.
Chemerin is a novel adipokine associated with obesity and metabolic syndrome. [Endocrinology. 2007]
Chemerin is a novel adipokine associated with obesity and metabolic syndrome.
Bozaoglu K, Bolton K, McMillan J, Zimmet P, Jowett J, Collier G, Walder K, Segal D. Endocrinology. 2007 Oct; 148(10):4687-94. Epub 2007 Jul 19.
Review Stress and vascular responses: atheroprotective effect of laminar fluid shear stress in endothelial cells: possible role of mitogen-activated protein kinases. [J Pharmacol Sci. 2003]
Review Stress and vascular responses: atheroprotective effect of laminar fluid shear stress in endothelial cells: possible role of mitogen-activated protein kinases.
Yoshizumi M, Abe J, Tsuchiya K, Berk BC, Tamaki T. J Pharmacol Sci. 2003 Mar; 91(3):172-6.
Review Chemerin and its receptors in leukocyte trafficking, inflammation and metabolism. [Cytokine Growth Factor Rev. 2011]
Review Chemerin and its receptors in leukocyte trafficking, inflammation and metabolism.
Bondue B, Wittamer V, Parmentier M. Cytokine Growth Factor Rev. 2011 Oct-Dec; 22(5-6):331-8. Epub 2011 Nov 25.

See reviews... See all...

Cited by 14 PubMed Central articles

Understanding resolvin signaling pathways to improve oral health. [Int J Mol Sci. 2013]
Understanding resolvin signaling pathways to improve oral health.
Keinan D, Leigh NJ, Nelson JW, De Oleo L, Baker OJ. Int J Mol Sci. 2013 Mar 8; 14(3):5501-18. Epub 2013 Mar 8.
Anti-TNF therapy reduces serum levels of chemerin in rheumatoid arthritis: a new mechanism by which anti-TNF might reduce inflammation. [PLoS One. 2013]
Anti-TNF therapy reduces serum levels of chemerin in rheumatoid arthritis: a new mechanism by which anti-TNF might reduce inflammation.
Herenius MM, Oliveira AS, Wijbrandts CA, Gerlag DM, Tak PP, Lebre MC. PLoS One. 2013; 8(2):e57802. Epub 2013 Feb 27.
Adipokines in psoriatic arthritis patients: the correlations with osteoclast precursors and bone erosions. [PLoS One. 2012]
Adipokines in psoriatic arthritis patients: the correlations with osteoclast precursors and bone erosions.
Xue Y, Jiang L, Cheng Q, Chen H, Yu Y, Lin Y, Yang X, Kong N, Zhu X, Xu X, et al. PLoS One. 2012; 7(10):e46740. Epub 2012 Oct 29.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (GeneRIF)
Gene records that have the current articles as Reference into Function citations (GeneRIFs). NLM staff reviewing the literature while indexing MEDLINE add GeneRIFs manually.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Identification of chemerin receptor (ChemR23) in human endothelial cells: chemer...
Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis.
Biochem Biophys Res Commun. 2010 Jan 22 ;391(4):1762-8. doi: 10.1016/j.bbrc.2009.12.150. Epub 2009 Dec 31 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: