Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Science. 2010 Feb 12;327(5967):876-9. doi: 10.1126/science.1182363. Epub 2009 Dec 31.

Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination.

Author information

  • 1Department of Statistics, Oxford University, 1 South Parks Road, Oxford OX1 3TG, UK. myers@stats.ox.ac.uk

Abstract

Although present in both humans and chimpanzees, recombination hotspots, at which meiotic crossover events cluster, differ markedly in their genomic location between the species. We report that a 13-base pair sequence motif previously associated with the activity of 40% of human hotspots does not function in chimpanzees and is being removed by self-destructive drive in the human lineage. Multiple lines of evidence suggest that the rapidly evolving zinc-finger protein PRDM9 binds to this motif and that sequence changes in the protein may be responsible for hotspot differences between species. The involvement of PRDM9, which causes histone H3 lysine 4 trimethylation, implies that there is a common mechanism for recombination hotspots in eukaryotes but raises questions about what forces have driven such rapid change.

Comment in

PMID:
20044541
[PubMed - indexed for MEDLINE]
PMCID:
PMC3828505
Free PMC Article

Images from this publication.See all images (2)Free text

Figure 1
Figure 2
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk