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    Int J Oncol. 2010 Feb;36(2):405-14.

    An 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer.

    Zhang X, Yang JJ, Kim YS, Kim KY, Ahn WS, Yang S.

    Source

    Cancer Metastasis Research Center, Yonsei University College of Medicine, Seoul 120-752, Korea.

    Abstract

    We have identified an 8-gene signature with significant expression differences between gastric cancer and normal gastric tissues. This 8-gene set can predict the normal and cancer status of gastric tissues with more than 96% accuracy in a totally independent microarray dataset. The 8 genes are composed of down-regulated KLF4, GPX3, SST and LIPF, together with up-regulated SERPINH1, THY1 and INHBA in gastric cancer. To corroborate the differential gene expression pattern, we chose GPX3 and examined its expression pattern in detail. A comparison of GPX3 expression pattern shows a broader down-regulated pattern in multiple types of cancers, including cervical, thyroid, head and neck, lung cancers and melanoma than in healthy controls. An immuno-histostaining analysis in tissue microarrays confirms GPX3 down-regulation in gastric cancer. Mechanism-wise GPX3 down-regulation in gastric cancer is due to promoter hypermethylation. Collectively, these results show a correct identification of 8 genes as gastric cancer biomarkers.

    PMID:
    20043075
    [PubMed - indexed for MEDLINE]

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