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J Cell Biol. 2009 Dec 28;187(7):945-57. doi: 10.1083/jcb.200904124.

Role of A-type lamins in signaling, transcription, and chromatin organization.

Author information

  • 1Department of Atherothrombosis and Cardiovascular Imaging, Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain. vandres@cnic.es

Abstract

A-type lamins (lamins A and C), encoded by the LMNA gene, are major protein constituents of the mammalian nuclear lamina, a complex structure that acts as a scaffold for protein complexes that regulate nuclear structure and functions. Interest in these proteins has increased in recent years with the discovery that LMNA mutations cause a variety of human diseases termed laminopathies, including progeroid syndromes and disorders that primarily affect striated muscle, adipose, bone, and neuronal tissues. In this review, we discuss recent research supporting the concept that lamin A/C and associated nuclear envelope proteins regulate gene expression in health and disease through interplay with signal transduction pathways, transcription factors, and chromatin-associated proteins.

PMID:
20038676
[PubMed - indexed for MEDLINE]
PMCID:
PMC2806284
Free PMC Article

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