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Mod Rheumatol. 2010 Apr;20(2):200-4. doi: 10.1007/s10165-009-0254-1.

Marked effect and steroid-sparing ability of anakinra on a patient with refractory adult-onset Still's disease.

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  • 1Section of Allergy and Rheumatology, St. Luke's International Hospital, 9-1 Akashi-cho, Chuo-ku Tokyo, 104-8560, Japan. chitama@luke.or.jp


We report a case of refractory adult-onset Still's disease (AOSD) successfully controlled with anakinra, an interleukin-1 (IL-1) receptor antagonist. The patient was a 23-year-old Japanese woman with AOSD who could not be induced into remission despite of two courses of pulsed methylprednisolone followed by high-dose glucocorticoid administration in conjunction with high-dose intravenously administered gamma-globulin and methotrexate. To the best of our knowledge, this is the first case report in Japan of AOSD remission induced with anakinra.

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