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Bioorg Med Chem Lett. 2010 Feb 1;20(3):1063-4. doi: 10.1016/j.bmcl.2009.12.034. Epub 2009 Dec 11.

Asymmetric syntheses of daedalin A and quercinol and their tyrosinase inhibitory activity.

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  • 1Sciences of Functional Foods, Graduate School of Agriculture, Shinshu University, 8304 Minami-minowa, Kami-ina, Nagano 399-4598, Japan.


Stereoselective syntheses of daedalin A and quercinol, an enantiomer of daedalin A, is described. The tyrosinase inhibitory activities of daedalin A and quercinol were examined. The activity of quercinol was weaker than that of daedalin A at high concentration.

Copyright (c) 2009 Elsevier Ltd. All rights reserved.

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