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FEBS Lett. 2010 May 17;584(10):2028-32. doi: 10.1016/j.febslet.2009.12.035. Epub 2009 Dec 24.

Properties of the intracellular transient receptor potential (TRP) channel in yeast, Yvc1.

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  • 1Experimentelle und Klinische Pharmakologie und Toxikologie, Medizinische Fakult├Ąt, Universit├Ąt des Saarlandes, 66421 Homburg, Germany. chang.yiming@uks.eu


Transient receptor potential (TRP) channels are found among mammals, flies, worms, ciliates, Chlamydomonas, and yeast but are absent in plants. These channels are believed to be tetramers of proteins containing six transmembrane domains (TMs). Their primary structures are diverse with sequence similarities only in some short amino acid sequence motifs mainly within sequences covering TM5, TM6, and adjacent domains. In the yeast genome, there is one gene encoding a TRP-like sequence. This protein forms an ion channel in the vacuolar membrane and is therefore called Yvc1 for yeast vacuolar conductance 1. In the following we summarize its prominent features.

Copyright 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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