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Hum Psychopharmacol. 2010 Mar;25(2):187-90. doi: 10.1002/hup.1089.

The effect of dopamine partial agonists on the nicotine dependency in patients with schizophrenia.

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  • 1Department of Psychiatry, Chung Ang University Hospital, Seoul, South Korea.

Abstract

OBJECTIVE:

We compared the effects of haloperidol and three atypical antipsychotics (risperidone, olanzapine, and aripiprazole) on nicotine dependence in schizophrenic patients.

METHODS:

One hundred and thirty nine schizophrenic patients, who began using antipsychotic medication, were assessed for severity of nicotine dependence and for cigarette craving at baseline and following 8 weeks of treatment using the Fagerström Tolerance Questionnaire (FTQ) and a Likert-style, seven point, visual-analogue rating scale.

RESULTS:

Nicotine dependence increased in the haloperidol group, but not in atypical antipsychotics groups. Patients treated with aripiprazole showed a reduction both in nicotine dependence and cigarette craving.

CONCLUSIONS:

The effects of aripiprazole, a partial agonist of the dopamine D2 receptor, may reduce the severity of nicotine dependence in schizophrenic patients.

Copyright 2009 John Wiley & Sons, Ltd.

PMID:
20033907
[PubMed - indexed for MEDLINE]
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