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Leuk Res. 2010 May;34(5):677-81. doi: 10.1016/j.leukres.2009.10.026. Epub 2009 Dec 23.

Micro-RNA-15a and micro-RNA-16 expression and chromosome 13 deletions in multiple myeloma.

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  • 1Department of Hematology, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands.


We have used copy number variation (CNV) analysis with SNP mapping arrays for miRNA-15a and miRNA-16-1 expression analysis in patients with multiple myeloma (MM) with or without deletion of chromosome 13q14. MiRNA-15a and miRNA-16 display a range of expression patterns in MM patients, independent of the chromosome 13 status. These findings suggest that genes other than miR-15a and miR-16 may explain the prognostic significance of 13q14 deletions.

Copyright (c) 2009 Elsevier Ltd. All rights reserved.

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