Am J Physiol Endocrinol Metab. 2010 Apr;298(4):E742-50. Epub 2009 Dec 22.

Emerging role of neuregulin as a modulator of muscle metabolism.

Gumà A, Martínez-Redondo V, López-Soldado I, Cantó C, Zorzano A.

Source

Dept. of Biochemistry and Molecular Biology, Univ. of Barcelona, Spain. aguma@ub.edu

Abstract

Neuregulin was described initially as a neurotrophic factor involved in the formation of the neuromuscular junction in skeletal muscle. However, in recent years, neuregulin has been reported to be a myokine that exerts relevant effects on myogenesis and the regulation of muscle metabolism. In this new context, the rapid and chronic metabolic effects of neuregulin appear to be related to muscle contraction. Indeed, the effects of neuregulin resemble those of exercise, which are accompanied by an improvement in insulin sensitivity. In this review, we challenge the classical role assigned to neuregulin in muscle and propound the emerging concept of its involvement in the regulation of energetic metabolism and insulin responsiveness.

PMID:: 20028964; [PubMed - indexed for MEDLINE]

Free full text

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Neuregulins mediate calcium-induced glucose transport during muscle contraction. [J Biol Chem. 2006]
Neuregulins mediate calcium-induced glucose transport during muscle contraction.
Cantó C, Chibalin AV, Barnes BR, Glund S, Suárez E, Ryder JW, Palacín M, Zierath JR, Zorzano A, Gumà A. J Biol Chem. 2006 Aug 4; 281(31):21690-7. Epub 2006 Jun 1.
Neuregulins increase mitochondrial oxidative capacity and insulin sensitivity in skeletal muscle cells. [Diabetes. 2007]
Neuregulins increase mitochondrial oxidative capacity and insulin sensitivity in skeletal muscle cells.
Cantó C, Pich S, Paz JC, Sanches R, Martínez V, Orpinell M, Palacín M, Zorzano A, Gumà A. Diabetes. 2007 Sep; 56(9):2185-93. Epub 2007 Jun 11.
Neuregulin expression at neuromuscular synapses is modulated by synaptic activity and neurotrophic factors. [J Neurosci. 2002]
Neuregulin expression at neuromuscular synapses is modulated by synaptic activity and neurotrophic factors.
Loeb JA, Hmadcha A, Fischbach GD, Land SJ, Zakarian VL. J Neurosci. 2002 Mar 15; 22(6):2206-14.
Review Intracellular signals involved in the effects of insulin-like growth factors and neuregulins on myofibre formation. [Cell Signal. 2003]
Review Intracellular signals involved in the effects of insulin-like growth factors and neuregulins on myofibre formation.
Zorzano A, Kaliman P, Gumà A, Palacín M. Cell Signal. 2003 Feb; 15(2):141-9.
Review Neuregulins at the neuromuscular synapse: past, present, and future. [J Neurosci Res. 2007]
Review Neuregulins at the neuromuscular synapse: past, present, and future.
Rimer M. J Neurosci Res. 2007 Jul; 85(9):1827-33.

See reviews... See all...

Cited by 2 PubMed Central articles

Mitochondria death/survival signaling pathways in cardiotoxicity induced by anthracyclines and anticancer-targeted therapies. [Biochem Res Int. 2012]
Mitochondria death/survival signaling pathways in cardiotoxicity induced by anthracyclines and anticancer-targeted therapies.
Montaigne D, Hurt C, Neviere R. Biochem Res Int. 2012; 2012:951539. Epub 2012 Mar 20.
Review Age-associated alterations of the neuromuscular junction. [Exp Gerontol. 2011]
Review Age-associated alterations of the neuromuscular junction.
Jang YC, Van Remmen H. Exp Gerontol. 2011 Feb-Mar; 46(2-3):193-8. Epub 2010 Sep 18.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Emerging role of neuregulin as a modulator of muscle metabolism.
Emerging role of neuregulin as a modulator of muscle metabolism.
Am J Physiol Endocrinol Metab. 2010 Apr ;298(4):E742-50. Epub 2009 Dec 22 .

PubMed
Characterizing hospitalizations of end-stage renal disease patients on dialysis ...
Characterizing hospitalizations of end-stage renal disease patients on dialysis and inpatient utilization of erythropoiesis-stimulating agent therapy.
Ann Pharmacother. 2010 Jan ;44(1):43-9. Epub 2009 Dec 22 .

PubMed
Lack of lipotoxicity effect on {beta}-cell dysfunction in ketosis-prone type 2 d...
Lack of lipotoxicity effect on {beta}-cell dysfunction in ketosis-prone type 2 diabetes.
Diabetes Care. 2010 Mar ;33(3):626-31. Epub 2009 Dec 22 .

PubMed
Systems biologists seek fuller integration of systems biology approaches in new ...
Systems biologists seek fuller integration of systems biology approaches in new cancer research programs.
Cancer Res. 2010 Jan 1 ;70(1):12-3. Epub 2009 Dec 22 .

PubMed
Central role of IFNgamma-indoleamine 2,3-dioxygenase axis in regulation of inter...
Central role of IFNgamma-indoleamine 2,3-dioxygenase axis in regulation of interleukin-12-mediated antitumor immunity.
Cancer Res. 2010 Jan 1 ;70(1):129-38. Epub 2009 Dec 22 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: