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Scand J Gastroenterol. 2010 Mar;45(3):261-72. doi: 10.3109/00365520903497098.

Clostridium difficile infection and inflammatory bowel disease.

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  • 1Department of Intensive Care Medicine, St. George's Hospital, London, UK. catchMusa@hotmail.com


The importance of Clostridium difficile (C. difficile) infection amongst patients with inflammatory bowel disease (IBD) is increasingly being recognized. Recent studies have demonstrated a concerning trend towards increased rates of infection, morbidity, mortality and health costs, and guidelines now promote testing for C. difficile in IBD patients experiencing a relapse. This critical review focuses on the epidemiology, risk factors, pathogenesis, treatment options and outcomes associated with C. difficile infection in patients with IBD.

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