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Analyst. 2010 Jan;135(1):127-32. doi: 10.1039/b921048b. Epub 2009 Nov 26.

Analytical protocol for identification of BMAA and DAB in biological samples.

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  • 1Department of Analytical Chemistry, Stockholm University, 10691 Stockholm, Sweden.


Beta-N-methylamino-L-alanine (BMAA) is a non-protein amino acid, thought to be inflicting neurodegenerative diseases related to ALS/PDC in human beings. Due to conflicting data concerning the presence of BMAA in various biological matrixes, we present a robust and sensitive method for high confidence identification of BMAA after derivatization by 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC). The efficient sample pretreatment in combination with LC-MS/MS SRM enables chromatographic separation of BMAA from the isomer 2,3-diaminobutyric acid (DAB). The method is applicable for selective BMAA/DAB detection in various biological samples ranging from a prokaryotic cyanobacterium to eukaryotic fish.

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