Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nat Prod Rep. 2010 Jan;27(1):11-22. doi: 10.1039/b920860g. Epub 2009 Oct 27.

Epigenome manipulation as a pathway to new natural product scaffolds and their congeners.

Author information

  • 1Natural Products Discovery Group and Graduate Program in Ecology and Evolutionary Biology, Department of Chemistry and Biochemistry, 620 Parrington Oval, Room 208, University of Oklahoma, Norman, OK 73019, USA. rhcichewicz@ou.edu

Abstract

The covalent modification of chromatin is an important control mechanism used by fungi to modulate the transcription of genes involved in secondary metabolite production. To date, both molecular-based and chemical approaches targeting histone and DNA posttranslational processes have shown great potential for rationally directing the activation and/or suppression of natural-product-encoding gene clusters. In this Highlight, the organization of the fungal epigenome is summarized and strategies for manipulating chromatin-related targets are presented. Applications of these techniques are illustrated using several recently published accounts in which chemical-epigenetic methods and mutant studies were successfully employed for the de novo or enhanced production of structurally diverse fungal natural products (e.g., anthraquinones, cladochromes, lunalides, mycotoxins, and nygerones).

PMID:
20024091
[PubMed - indexed for MEDLINE]
PMCID:
PMC2958777
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Royal Society of Chemistry Icon for PubMed Central
    Loading ...
    Write to the Help Desk