A synthetic isoquinoline alkaloid, 1-(beta-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (YS 51), reduces inducible nitric oxide synthase expression and improves survival in a rodent model of endotoxic shock.
Kang YJ, Seo SJ, Yun-Choi HS, Lee DH, Kim YM, Chang KC. J Pharmacol Exp Ther. 2002 May; 301(2):561-7.