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Am J Pathol. 2010 Jan;176(1):2-13. doi: 10.2353/ajpath.2010.090675. Epub 2009 Dec 17.

Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas.

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  • 1University of Pittsburgh, Department of Pathology, School of Medicine, S-410 Biomedical Science Tower, Pittsburgh, PA 15261, USA.


Liver regeneration after partial hepatectomy is one of the most studied models of cell, organ, and tissue regeneration. The complexity of the signaling pathways initiating and terminating this process have provided paradigms for regenerative medicine. Many aspects of the signaling mechanisms involved in hepatic regeneration are under active investigation. The purpose of this review is to focus on the areas still not well understood. The review also aims to provide insights into the ways by which current concepts of liver regeneration can provide understanding regarding malfunction of the regenerative process in liver diseases, such as acute liver failure.

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