N Engl J Med. 2009 Dec 31;361(27):2599-608. doi: 10.1056/NEJMoa0904006. Epub 2009 Dec 16.

MMP12, lung function, and COPD in high-risk populations.

Source

Channing Laboratory and Center for Genomic Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

Abstract

BACKGROUND:

Genetic variants influencing lung function in children and adults may ultimately lead to the development of chronic obstructive pulmonary disease (COPD), particularly in high-risk groups.

METHODS:

We tested for an association between single-nucleotide polymorphisms (SNPs) in the gene encoding matrix metalloproteinase 12 (MMP12) and a measure of lung function (prebronchodilator forced expiratory volume in 1 second [FEV(1)]) in more than 8300 subjects in seven cohorts that included children and adults. Within the Normative Aging Study (NAS), a cohort of initially healthy adult men, we tested for an association between SNPs that were associated with FEV(1) and the time to the onset of COPD. We then examined the relationship between MMP12 SNPs and COPD in two cohorts of adults with COPD or at risk for COPD.

RESULTS:

The minor allele (G) of a functional variant in the promoter region of MMP12 (rs2276109 [-82A-->G]) was positively associated with FEV(1) in a combined analysis of children with asthma and adult former and current smokers in all cohorts (P=2x10(-6)). This allele was also associated with a reduced risk of the onset of COPD in the NAS cohort (hazard ratio, 0.65; 95% confidence interval [CI], 0.46 to 0.92; P=0.02) and with a reduced risk of COPD in a cohort of smokers (odds ratio, 0.63; 95% CI, 0.45 to 0.88; P=0.005) and among participants in a family-based study of early-onset COPD (P=0.006).

CONCLUSIONS:

The minor allele of a SNP in MMP12 (rs2276109) is associated with a positive effect on lung function in children with asthma and in adults who smoke. This allele is also associated with a reduced risk of COPD in adult smokers.

2009 Massachusetts Medical Society

Comment in

Matrix metalloproteinase 12, asthma, and COPD. [N Engl J Med. 2009]
Matrix metalloproteinase 12, asthma, and COPD.Brusselle GG. N Engl J Med. 2009 Dec 31; 361(27):2664-5. Epub 2009 Dec 16.
MMP12, lung function, and COPD in high-risk populations. [N Engl J Med. 2010]
MMP12, lung function, and COPD in high-risk populations.Morita H, Nagai R. N Engl J Med. 2010 Apr 1; 362(13):1241; author reply 1242.
MMP12, lung function, and COPD in high-risk populations. [N Engl J Med. 2010]
MMP12, lung function, and COPD in high-risk populations.Elkington PT, Cooke GS. N Engl J Med. 2010 Apr 1; 362(13):1241; author reply 1242.