Arch Pediatr. 2010 Feb;17(2):159-65. Epub 2009 Dec 16.

[Diffuse intrinsic brain stem glioma in children: current treatment and future directions].

[Article in French]

Leblond P, Vinchon M, Bernier-Chastagner V, Chastagner P.

Source

Unité d'oncologie pédiatrique, centre Oscar-Lambret, 59020 Lille cedex, France. p-leblond@o-lambret.fr

Abstract

Despite the numerous clinical trials undertaken, the prognosis of children with diffuse brain stem glioma remains very poor. This review examines the different strategies for the treatment of malignant brain stem glioma such as radiation therapy, concurrent radiochemotherapy, and classical cytotoxic drugs, with a particular focus on the novel targeted and antiangiogenic drugs recently introduced in pediatric oncology. The strategy using integrin inhibitors is discussed.

PMID:: 20018494; [PubMed - indexed for MEDLINE]

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