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J Med Chem. 2009 Dec 24;52(24):7934-7. doi: 10.1021/jm901044z.

N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase.

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  • 1Novartis Institute for Tropical Diseases, Chromos, 138670, Singapore.

Abstract

A novel class of compounds containing N-sulfonylanthranilic acid was found to specifically inhibit dengue viral polymerase. The structural requirements for inhibition and a preliminary structure-activity relationship are described. A UV cross-linking experiment was used to map the allosteric binding site of the compound on the viral polymerase.

PMID:
20014868
[PubMed - indexed for MEDLINE]
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