Comparative analysis of Micrococcus luteus isolates from blood cultures of patients with pulmonary hypertension receiving epoprostenol continuous infusion

Yoshinori Hirata; Makoto Sata; Yuko Makiuchi; Keita Morikane; Akihito Wada; Nobuhiko Okabe; Hitonobu Tomoike

doi:10.1007/s10156-009-0720-x

Comparative analysis of Micrococcus luteus isolates from blood cultures of patients with pulmonary hypertension receiving epoprostenol continuous infusion

J Infect Chemother. 2009 Dec;15(6):424-5. doi: 10.1007/s10156-009-0720-x.

Authors

Yoshinori Hirata¹, Makoto Sata, Yuko Makiuchi, Keita Morikane, Akihito Wada, Nobuhiko Okabe, Hitonobu Tomoike

Affiliation

¹ Department of Clinical Laboratory, National Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka, 565-8565, Japan.

PMID: 20012737
DOI: 10.1007/s10156-009-0720-x

Abstract

During the period 2002-2008, at the National Cardiovascular Center, Osaka, 28 Micrococcus luteus isolates and one Kocuria spp. isolate were obtained from blood cultures of pulmonary hypertension (PH) patients who were receiving continuous infusion therapy with epoprostenol. Pulsed-field gel electrophoresis patterns of the isolates were unrelated, suggesting that the infections had multiple origins. The preparation of epoprostenol solution by patients themselves was thought to be a risk factor.

MeSH terms

Antihypertensive Agents / administration & dosage
Catheters, Indwelling / microbiology
Drug Contamination
Electrophoresis, Gel, Pulsed-Field
Epoprostenol / administration & dosage*
Gram-Positive Bacterial Infections / blood*
Gram-Positive Bacterial Infections / drug therapy
Gram-Positive Bacterial Infections / microbiology*
Humans
Hypertension, Pulmonary / blood
Hypertension, Pulmonary / drug therapy
Hypertension, Pulmonary / microbiology*
Infusions, Intravenous
Micrococcus luteus / genetics
Micrococcus luteus / isolation & purification*
Platelet Aggregation Inhibitors / administration & dosage

Substances

Antihypertensive Agents
Platelet Aggregation Inhibitors
Epoprostenol