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Methods Mol Biol. 2010;602:55-77. doi: 10.1007/978-1-60761-058-8_4.

Engineering the mouse genome to model human disease for drug discovery.

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  • 1Ozgene Pty. Ltd., Bentley DC, WA, Australia.

Abstract

Genetically engineered mice (GEM) have become invaluable tools for human disease modeling and drug development. Completion of the mouse genome sequence in combination with transgenesis and gene targeting in embryonal stem cells have opened up unprecedented opportunities. Advanced technologies for derivation of GEM models will be introduced and discussed.

PMID:
20012392
[PubMed - indexed for MEDLINE]
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